The microcirculation during endotoxemia

Endotoxemia within the Liver Microcirculation during The Role of CD14 in Neutrophil Recruitment

Citrulline a More Suitable Substrate than Arginine to Restore NO Production and the Microcirculation during Endotoxemia

BACKGROUND Impaired microcirculation during endotoxemia correlates with a disturbed arginine-nitric oxide (NO) metabolism and is associated with deteriorating organ function. Improving the organ perfusion in endotoxemia, as often seen in patients with severe infection or systemic inflammatory response syndrome (SIRS) is, therefore, an important therapeutic target. We hypothesized that supplemen...

Nitric oxide measurements during endotoxemia.

BACKGROUND Excessive continuous NO release from inducible NO synthase over prolonged periods under pathological conditions, such as endotoxemia, contributes significantly to circulatory failure, hypotension, and septic shock. This NO production during endotoxemia is accompanied by superoxide release, which contributes to the fast decay of NO. Therefore, the amount of NO that diffuses to target ...

Experimental endotoxemia induces leukocyte adherence and plasma extravasation within the rat pial microcirculation.

Disturbance of capillary perfusions due to leukocyte adhesion, disseminated intravascular coagulation, tissue edema is critical components in the pathophysiology of sepsis. Alterations in brain microcirculation during sepsis are not clearly understood. The aim of this study is to gain an improved understanding of alterations through direct visualization of brain microcirculations in an experime...

The relationships among acute phase response proteins, cytokines, and enzymes during ovine experimental endotoxemia

BACKGROUND: The acute phase response is beneficial to theanimal in restoring homeostasis, and measuring the circulatingacute phase proteins, cytokines, and enzymes can be used toevaluate the innate immune system's responses to invader agentssuch as bacterial lipopolysaccharide. Measurement of theseparameters has shown to be useful as diagnostic and prognosticmarkers in animal endotoxemia. OBJEC...